The resurrection of spironolactone on its golden anniversary.

Exploring 70 Years of the British National Health Service through Anniversary Documents

The British National Health Service (NHS) celebrates its 70th birthday on July 5, 2018. This article examines this anniversary through the lens of previous anniversaries. It examines seven documents close to each anniversary over a period of some 60 years, drawing on interpretive content analysis, based on the narrative dimensions of context (structure and finance); success or achievements; pro...

Iranian Journal of Basic Medical Sciences comes of age on the 20th anniversary of publication

Effects of additive therapy with spironolactone on albuminuria in diabetes mellitus: A pilot randomized clinical trial

Background: Early diagnosis of albuminuria and the prevention of its progression to macroalbuminuria and diabetic nephropathy are crucial. Angiotensin converting enzyme inhibitors (ACEIs) and antagonists of angiotensin II receptors type I (ARBs) are currently used as first-line treatment for albuminuria in these patients. The present study was conducted to assess the efficacy of addition of spi...

Spironolactone Inhibits NADPH Oxidase-Mediated Oxidative Stress and Dysregulation of the Endothelial NO Synthase in Human Endothelial Cells

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

“The Phoenix” by Nima Yushij and George Darley: The Poet-bird’s Yearning for a Resurrection of Poetry

At the time of its publication, Nima Yushij’s “Qoqnus” (The Phoenix) emerged as a radical departure from the norms and conventions of classical Persian poetry. Nima employed phoenix symbolism in this poem to present his zeal for a literary renaissance. Likewise, George Darley (1795-1846), the Irish Romantic poet who found himself lonely and isolated at the mitigating time borders of Romanticism...